Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Good
Based on 27 Reviews
8.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
8 mg
<1%
Hyaluronic Acid (from Sodium Hyaluronate)
120 mg
†
Top Medical Research Studies
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
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2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
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Most Useful Reviews
9
Bursitis pain relief
121 people found this helpful
I love this product! After suffering from bursitis pain in my shoulder for two years, I sought an alternative to prescribed medications. This has reduced my pain by 95% within four days! I take it daily and will not go without it.
Read More
10
Eliminated back pain
32 people found this helpful
I take this alongside collagen and glucosamine for my joints, skin, hair, and nails. After three months, I noticed a significant improvement—my back pain, which was excruciating, has now disappeared! I will certainly continue this course. A quality hyaluronic acid from a reputable manufacturer!
Read More
9
Reduced joint pain
25 people found this helpful
It WORKS! I’ve been taking this for about a year after hearing about it on the radio. It’s much cheaper than other options. Within three days, I felt a difference in my hips. The sandpaper-like sensation in my joints is gone, and I can now walk without pain. If your joints ache, I strongly recommend trying this.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
8
We examined the effects of hyaluronic acid in healing back pain linked to disc degeneration. In our study, New Zealand white rabbits undergoing a partial nucleotomy received either PGA/HA implants or bioactivated fibrin, while controls underwent the procedure without any treatment.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
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8
Sacroiliac joint pain treatment review
We explored the complex nature of chronic pain in the sacroiliac joint, which has long sparked debate due to its anatomical position. This makes accurate diagnosis challenging, often requiring advanced techniques like guided injections.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
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7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
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User Reviews
USERS' SCORE
Good
Based on 27 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Bursitis pain relief
121 people found this helpful
I love this product! After suffering from bursitis pain in my shoulder for two years, I sought an alternative to prescribed medications. This has reduced my pain by 95% within four days! I take it daily and will not go without it.
Read More
10
Eliminated back pain
32 people found this helpful
I take this alongside collagen and glucosamine for my joints, skin, hair, and nails. After three months, I noticed a significant improvement—my back pain, which was excruciating, has now disappeared! I will certainly continue this course. A quality hyaluronic acid from a reputable manufacturer!
Read More
9
Reduced joint pain
25 people found this helpful
It WORKS! I’ve been taking this for about a year after hearing about it on the radio. It’s much cheaper than other options. Within three days, I felt a difference in my hips. The sandpaper-like sensation in my joints is gone, and I can now walk without pain. If your joints ache, I strongly recommend trying this.
Read More
9
Significant back relief
19 people found this helpful
Wonderful sorcery. Great for aches and pains. I started taking it after experiencing tight back pain from the day before. Nothing worked—12-hour pain meds, turmeric, fish oil. Just as I was ready to give up, I remembered this yellow bottle. After a few doses, within two hours, I stopped hunching over in pain and felt rejuvenated. I’ve been taking it daily with great success. It’s not just helped my back pain; my hair has also become noticeably shinier. What a transformation!
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9
Knee pain relief
15 people found this helpful
This product has been very helpful for my husband and me over the past two years. In our 60s, we both struggle with knee pain, and hyaluronic acid truly helps. When we run out, we notice a visible increase in our pain level.
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Frequently Asked Questions
9
Hot flash relief
2 people found this helpful
Thanks to Jarrow Formulas, within just two days of taking hyaluronic acid, my back pain from old injuries improved dramatically, and my hot flashes ceased. I'm now much more mobile at work.
8
Strengthened support
9 people found this helpful
I have mild degenerative disc disease and sought to alleviate my lower back pain. Combining this hyaluronic acid with type II collagen has led to significant improvement over the past month. I now feel stronger and more active, and the product offers excellent value.
10
Eliminated back pain
32 people found this helpful
I take this alongside collagen and glucosamine for my joints, skin, hair, and nails. After three months, I noticed a significant improvement—my back pain, which was excruciating, has now disappeared! I will certainly continue this course. A quality hyaluronic acid from a reputable manufacturer!
7.5
Joint pain relief
4 people found this helpful
I combine hyaluronic acid with chondroprotectors and vitamin C. It significantly alleviates my chronic back pain caused by hereditary issues. I advise taking it consistently for six months, followed by a three-month break, to ensure its effectiveness.
9
Knee pain relief
15 people found this helpful
This product has been very helpful for my husband and me over the past two years. In our 60s, we both struggle with knee pain, and hyaluronic acid truly helps. When we run out, we notice a visible increase in our pain level.
9
Reduced joint pain
25 people found this helpful
It WORKS! I’ve been taking this for about a year after hearing about it on the radio. It’s much cheaper than other options. Within three days, I felt a difference in my hips. The sandpaper-like sensation in my joints is gone, and I can now walk without pain. If your joints ache, I strongly recommend trying this.
9
SI joint relief
3 people found this helpful
Excellent! This hyaluronic acid relieved my SI joint pain within an hour of taking it. I now take two capsules daily, and after a week, my back pain is almost entirely gone.
6
Back pain solution
1 people found this helpful
I initially bought it for my skin, but it remarkably alleviated my back pain. However, I experience edema if I take it long-term, so I only use it as needed.
7
We explored the impact of combining therapeutic exercise with dietary supplements, including hyaluronic acid, on chronic low back pain. In this study, 60 patients were split into two groups—one receiving only exercise and the other incorporating these supplements.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
5
Hyaluronic acid shows limited benefits
We undertook a double-blind, randomized controlled trial involving 30 participants to compare hyaluronic acid (HA) with triamcinolone for treating chronic low back pain linked to specific joint issues.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
After evaluating pain and disability scores over six months, we observed that both treatments yielded similar results, with both groups reporting short-term functional improvements. However, HA injection resulted in significant long-term functional enhancements and some short-term pain relief.
In contrast, triamcinolone provided only limited short-term benefits, indicating that while HA shows promise, it might not be a clear winner over triamcinolone in overall pain relief.
4
We examined the effectiveness of hyaluronic acid in managing chronic low back pain originating from facet joint osteoarthritis. Our systematic review analyzed various injectable treatments, focusing on outcomes from randomized clinical trials.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
While steroids and local anesthetics showed promising results, hyaluronic acid did not demonstrate significant benefits, unlike other treatments we explored.
Overall, injections for this type of back pain are encouraging, especially with medial branch blocks, but the role of hyaluronic acid remains unclear.
7
Hyaluronic acid shows limited benefit
We evaluated the safety and effectiveness of injecting mesenchymal precursor cells and hyaluronic acid (HA) in individuals suffering from chronic low back pain linked to degenerative disc disease. In a multicenter study involving 100 participants, we measured their pain and disability levels using visual scales and questionnaires at various intervals over three years.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
References
- Lee DH, Park KS, Shin HE, Kim SB, Choi H, et al. Safety and Feasibility of Intradiscal Administration of Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids for Chronic Discogenic Low Back Pain: Phase 1 Clinical Trial. Int J Mol Sci. 2023;24. doi:10.3390/ijms242316827
- Goode AP, Cleveland RJ, Kraus VB, Taylor KA, George SZ, et al. Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2023;31:809. doi:10.1016/j.joca.2023.02.005
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. doi:10.17116/kurort20229904120
- Baroncini A, Maffulli N, Eschweiler J, Knobe M, Tingart M, et al. Management of facet joints osteoarthritis associated with chronic low back pain: A systematic review. Surgeon. 2021;19:e512. doi:10.1016/j.surge.2020.12.004
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. doi:10.2174/1871530321666210210153619
- Amirdelfan K, Bae H, McJunkin T, DePalma M, Kim K, et al. Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy. Spine J. 2021;21:212. doi:10.1016/j.spinee.2020.10.004
- Annaswamy TM, Armstead C, Carlson L, Elkins NJ, Kocak D, et al. Intra-articular Triamcinolone Versus Hyaluronate Injections for Low Back Pain With Symptoms Suggestive of Lumbar Zygapophyseal Joint Arthropathy: A Pragmatic, Double-Blind Randomized Controlled Trial. Am J Phys Med Rehabil. 2018;97:278. doi:10.1097/PHM.0000000000000879
- Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther. 2017;8:262. doi:10.1186/s13287-017-0710-3
- Wu CY, Huang YH, Lee JS, Tai TW, Wu PT, et al. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299. doi:10.1002/jor.23001
- Endres M, Zenclussen ML, Casalis PA, Freymann U, Gil Garcia S, et al. Augmentation and repair tissue formation of the nucleus pulposus after partial nucleotomy in a rabbit model. Tissue Cell. 2014;46:505. doi:10.1016/j.tice.2014.09.003
- Cleary M, Keating C, Poynton AR. Viscosupplementation in lumbar facet joint arthropathy: a pilot study. J Spinal Disord Tech. 2008;21:29. doi:10.1097/BSD.0b013e318057720c
- Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493.
- Calvillo O, Skaribas I, Turnipseed J. Anatomy and pathophysiology of the sacroiliac joint. Curr Rev Pain. 2000;4:356.
- Srejic U, Calvillo O, Kabakibou K. Viscosupplementation: a new concept in the treatment of sacroiliac joint syndrome: a preliminary report of four cases. Reg Anesth Pain Med. 1999;24:84.
